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Motivation and Research Objectives

Ageing has a profound impact on human society and modern medicine, yet it remains a major puzzle of biology. Our group aims to help understand the genetic, cellular, and molecular mechanisms of ageing. Although our research integrates different strategies, its focal point is developing and applying experimental and computational methods that help bridge the gap between genotype and phenotype, a major challenge of the post-genome era, and help decipher the human genome and how it regulates complex processes like ageing and age-related diseases.

In the long-term, we would like our work to contribute to the development of interventions that preserve health and combat disease by manipulating the ageing process. By studying the mechanisms of ageing our work could also have an impact on diseases, like cancer and neurodegenerative diseases, for which age is a major risk factor. No other biomedical field has so much potential to improve human health as research on the basic mechanisms of ageing.

Biologists can be divided into two classes: experimentalists who observe things that cannot be explained, and theoreticians who explain things that cannot be observed

Aharon Katzir-Katchalsky